Could the Vice Presidential picks be the most consequential in US history?

The latest "hotness" on right wing websites is discussion about Hillary's health.  I don't know whether the lady is jacked up or not, what I do know is that even without the video editing it does look like something weird is going on with her.

Moving over to Trump, its apparent that the guy is more interested in the "movement" and not actually governing.  Quite honestly I'm not entirely sure he wants to be president.

Having said all that are we looking at another first in American history?  Are we looking at a time where the VP picks are consequential because the actual presidential candidates are almost doomed to a crackup of some type?

Are we doing this wrong?  Do we need to do a deep dive on Pence and Kaine?